Anti-ulcerogenic Effect of Morinda Citrifolia in Various Experimental Models
نویسندگان
چکیده
Morinda citrifolia is a member of the Rubiaceae. It is a Shrub or compacted to twisted small tree up to 8 m high with square stems and large stipules between nodes and petioles. Leaves are opposite, petiolate, glossy, mostly ovate, 15-35 cm long. Flowers white, up to 15 mm long, with a tubular corolla and 5 spreading lobes, the flowers borne on a globose syncarp. Fruit a large fleshy syncarp up to 15 cm long, at first green but becoming white, juicy, and pungent when mature. Flowers and fruits are available throughout the year. To investigate the phytoconstituents, acute oral toxicity and anti-ulcer profile of the Ethanol extract of Morinda citrifolia leaf extract in albino rats. Ethanolic extract at the doses of 200 and 400 mg/kg p.o administered to evaluate anti-ulcer activity by using Ethanol, indomethacin, and cold-restraint stress induced gastric ulcer models in Albino rats. Ethanol extract gave positive results for the alkaloids, reducing sugars, triterpenoids, and flavonoids. Study on acute toxicity of extract was found to be safe at the doses 2000mg/kg p.o. Ethanol extract dose dependent inhibition in ethanol induced gastric lesions, ethanol extract showed 68.3% % protection at 400 mg/kg, and 51.7% protection at 200 mg/kg, In indomethacin induced gastric lesions, Ethanol extract showed 75.02% protection at 400 mg/kg and 45.86% protection at 200 mg/kg, it also dose dependent inhibition in Cold-restraint stress induced gastric lesions, ethanol extract showed 75.45% protection at 400 mg/kg, and 50.34% protection at 200 mg/kg. All the results are found to be statistically significant (p≤0.05). Hence we suggest that ethanol extract possess antiulcerogenic properties that may be due to cytoprotective mechanism. These results support the ethnomedical uses of the plant in the treatment of gastric ulcer.
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